SAMHD1 expression has been shown to regulate the response of cancer cells to cytarabine (ara-C) [103,211], arabinosylguanine (AraG) [212], and 2′-C-cyano-2′-deoxy-1-β-D-arabino-pentofuranosyl-cytosine (CNDAC) [213]. This evidence concerns the gene SAMHD1 and cancer.