Cytokines which were significantly lower in CHC patients before treatment onset compared to healthy individuals were: IL-10 (medians 1.2 and 3.0 pg/mL, p = 0.007), IL-13 (medians 8.2 and 14.9 pg/mL, p < 0.001), IL-4 (medians 1.7 and 2.0 pg/mL, p < 0.001), IL-5 (medians 4.5 and 12.8 pg/mL, p = 0.041), IL-9 (medians 3.6 and 6.0 pg/mL, p = 0.005) and TNF-α (medians 4.5 and 6.0 pg/mL, p = 0.009). Here, IL5 is linked to cryohydrocytosis.