When comparing cytokine levels in CHC patients and healthy individuals, we found that CHC patients showed lower levels of proinflammatory cytokine TNF-α, anti-inflammatory cytokine IL-10, Th2 cytokines (IL-4, IL-5 and IL-13), Th22 cytokines (IL-22) and Th9 cytokines (IL-9) before starting DAA treatment and after achieving SVR. Here, IL5 is linked to cryohydrocytosis.