Using a multivariate logistic regression model to adjust for age, gender, race, prior IBD-related surgery, disease duration, and complex CD behavior, FAP status was found to be independently associated with protection from surgery during the follow-up period after initiation of a biologic (odds ratio: 0.28, 95% confidence interval (CI) [0.08–0.91]). This evidence concerns the gene FAP and inflammatory bowel disease.