Therefore, we attempted to elucidate the risk factors for hemangioma-related complications on the basis of echo findings, platelet counts and coagulation fibrinolytic markers (PT, fibrinogen, TAT, d-dimer, and FDP) and found that the predictive factors that require attention when evaluating patients with hemangiomas were a tumor size of >5 cm in diameter and coagulopathy, mainly the elevation of d-dimer (>5.0 μg/mL), and secondarily, the decrease in platelets and fibrinogen and the elevation of TAT and FDP. This evidence concerns the gene F2 and neoplasm.