The findings of the present study are as follows: (1) the DPP-4 and adiponectin levels were overexpressed in the SAT rather than in the EAT; (2) the DPP-4 and DPP-4 activity levels in the serum did not correlate with the DPP-4 levels in the SAT and EAT, but there was a positive correlation between the DPP-4 levels and the SAT and EAT; (3) the DPP-4 levels in the SAT showed a significantly positive correlation with atherosclerosis, DM, DPP-4-inhibitor use, and FBG levels. Here, DPP4 is linked to atherosclerosis.