VEGFA and acute myocardial infarction: They revealed that the concomitant presence of the CC genotype of VEGF, the A allele of IL-10, and the A allele of IFN-γ genes was associated with an increased risk of acute myocardial infarction and was more frequent among patients with a positive parental history of acute myocardial infarction, which confirmed that these genes with immune regulatory functions are part of the complex genetic background contributing to familiarity for CVDs [64].