DSP and familial dilated cardiomyopathy: Smith et al. (2020) collected a series of patients carrying DSP truncating mutations, proposing the term “desmoplakin cardiomyopathy” to describe a clinical phenotype characterized by a large amount of LV fibrosis, episodes of myocardial necrosis and a significant degree of electrical instability, and who entered into differential diagnosis with both ACM and DCM [11].