Circulating CD4+ T cells from MS patients were indeed demonstrated to recognise myelin basic protein (MBP), proteolipid protein (PLP), and myelin oligodendrocyte glycoprotein (MOG), even if the same phenomenon was also observed in healthy individuals; evidence regarding potential differences between these groups in frequency and avidity of cell interactions is conflicting [17,18]. This evidence concerns the gene CD4 and myeloid sarcoma.