MS was traditionally considered a T-cell-mediated autoimmune disorder, based on preclinical data from animal models of the disease (experimental autoimmune encephalomyelitis—EAE) and evidence for T-cell infiltration in inflammatory lesions and normal-appearing white matter of autoptic and biopsy CNS specimens from affected individuals, with an association between CD8+ T cells number and axonal damage [5,6,7,8,9,10,11,12]. Here, CD8A is linked to myeloid sarcoma.