Our paper is a prospective, observational study evaluating the early effects of ELX/TEZ/IVA on anatomical structure using MRI scores in three unselected adult CF patients (two females and one male; CFTR genotype: F508del in trans with N1303K, R553Q, and L1065P, respectively; age at the first chest MRI of 32, 43, and 20 years), followed at the CF center of Florence, Italy. Here, CFTR is linked to cystic fibrosis.