It was found that the methylation level of melanoma-related genes was strongly correlated with gene expression (Figure 3B and Supplementary Figure S1) as follows: KRT18 (correlation coefficient = −0.8219), CDK2 (corr_Coeff = −0.71693), JAK3 (corr_Coeff = −0.66835), BCL2 (corr_Coeff = −0.65555), MITF (corr_Coeff = −0.65016), MET (corr_Coeff = −0.59344), CXCL10 (corr_Coeff = −0.57735), EGF (corr_Coeff = −0.57576), SOX10 (corr_Coeff = −0.52463), SOCS3 (corr_Coeff = −0.50564), and KIT (corr_Coeff = −0.5003). This evidence concerns the gene JAK3 and melanoma.