Subgroup analysis conducted following sex stratification did not show significant interactions between sex and the other variables (i.e., age, BMI, EuroSCORE II, AV cusp number, congestive heart disease, cerebrovascular disease, chronic kidney disease, diabetes mellitus type 2 on insulin, or calcium channel blocker medication) that were identified as significant risk factors for long-term mortality in the univariate Cox proportional hazards regression analysis (Figure S1). This evidence concerns the gene INS and cerebrovascular disorder.