ESR1 and metabolic syndrome: Some studies have shown that ERα Xba I and Pvu II polymorphisms are associated with the risk of such diseases in menopausal women as osteoporosis, cardiovascular disease, endometriosis, neoplasms, systemic lupus erythematosus, Alzheimer’s disease, dyslipidemia, hypertension, and coronary atherosclerosis [12,13,14,15].