Functionally, MANCR downregulates miR-122a in hepatocellular carcinoma [58], and a recent study shows that bromodomain protein 4 (BRD4), a member of the bromodomain and extra-terminal domain (BET) family of nuclear proteins, binds the super-enhancer region of MANCR locus, which in turn, influences the migration and invasion of prostate cancer cell line PC3 [59]. This evidence concerns the gene BRD4 and hepatocellular carcinoma.