TREM2 and metabolic dysfunction-associated steatotic liver disease: Indeed, among 24 commonly up- and 14 down-regulated protein-coding genes, well-known markers of advanced NAFLD [e.g., aldo-keto reductase family 1 member B10 (AKR1B10) [40,41], cell death inducing DFFA like effector c (CIDEC) [42,43,44], lipoprotein lipase (LPL) [45,46], platelet derived growth factor subunit A (PDGFA) [47], triggering receptor expressed on myeloid cells 2 (TREM2) [48,49,50,51], and thymidylate synthetase (TYMS) [52] are consistently up-regulated.