FGF21 and metabolic dysfunction-associated steatotic liver disease: When silenced in Huh-7 cells by siRNAs (Figure 4A), a differential expression of several genes was observed in LINC01639 silenced cells compared to the control (cells treated with siRNA against scrambled sequence), including significant downregulation in the expression of NAFLD-linked (TYMS, DUSP2, SRF) TNF/TGF, and cytokine signaling (CXCL3, TNFRSF10D) and apoptosis-related genes (BAD), as well as growth factors FGF21 and IGF1 (Figure 4B).