The co-expressed genes in both normal and tumor samples were markedly enriched in the nucleoplasm and nuclear lumen (Figure 10b) and were significantly involved in binding nucleic acids (especially DNA) (Figure 10c); this is interesting as THAP9 also appears to localize in the nucleus [92] and possibly binds DNA via an amino terminal DNA-binding THAP domain [17]. This evidence concerns the gene THAP9 and neoplasm.