The mechanism of the protective effect of exercise has been proposed to be the protection of patients from central and general obesity [16,17] and diabetes [18]; a reduction in total cholesterol, triglycerides [19], and insulin resistance [20]; and an increase in plasma cholecystokinin [21] and vagal tone [22], which stimulates gallbladder contraction and emptying. Here, CCK is linked to obesity due to melanocortin 4 receptor deficiency.