The role of enhanced polyamine synthesis (ODC induction) in the prevention of tissue injury (e.g., cerebral IRI) [152,153,154,155], the development of neoplasia (e.g., MYC amplified tumors) [140,141], as well as developmental abnormalities (e.g., Bachmann–Bupp and Robinson–Snyder Syndromes) [156,161] has been documented. The gene discussed is MYC; the disease is neoplasm.