Based on 944 patients with PCa who underwent RARP at Karolinska University Hospital with a median follow-up period of 6.3 years, preoperative PSA > 10 ng/mL, pathological GS ≥ 4 + 3, pathological T3 disease, PSM, and lower surgeon volume were associated with an increased risk of BCR in multivariate analysis [20]. This evidence concerns the gene KLK3 and posterior cortical atrophy.