Hsieh Paishiun et al. described that knockout of autophagy transcriptional regulator Kruppel-like transcription factor-4 (KLF4) in the endothelium results in a stunted in vivo response to the vasodilator acetylcholine, indicative of endothelial dysfunction through suppressing autophagy [43]. This evidence concerns the gene KLF4 and endothelial dysfunction.