LV enlargement was observed only in one patient (P13) with an ACTN2 molecular variant during ECG and CMR examinations, while the remaining patients with LP variant in LAMA4 (P1) and with VUS in the MYH6, RBM20 and ACTC1 (P11, P12 and P16) presented no HF features. This evidence concerns the gene ACTN2 and hydrops fetalis.