Among those who developed symptoms of HF (LVEF reduction and LV enlargement) were patients P9 (novel pathogenic PRDM16 complex rearrangement c.1286_1289delinsTTGCACTT p.(Gly429Valfs*176)) and P7 with additional sinus bradycardia (novel likely pathogenic MYH7 c.3973-2A>C p.? Here, PRDM16 is linked to hydrops fetalis.