It should be highlighted that the p.Ser526Pro variant was found in the S1 domain, p.Asn615Ile in pore while p.Arg682Cys and p.Thr685Pro were found in the S2 domain; S1 and S2 form the ligand-binding domain, pore; re-entrant pore-forming and transmembrane spanning domains, which consequently may account for the change in spatial conformation and, as a result, instability of the “GluN2B subunit of N-methyl-D-aspartate receptors” complex, which may be a beneficial risk factor for neurodevelopmental disorders. This evidence concerns the gene GRIN2B and neurodevelopmental disorder.