HMOX1 and myeloid sarcoma: Chronic oral administration with AKBA 50 and 100 mg/kg significantly increased the HO-1 level in rat brain homogenate (one-way ANOVA: F(5,25) = 2.376, p < 0.001) and CSF (one-way ANOVA: F(5,25) = 0.296, p < 0.001) as compared to the EB-induced MS rats.