They found that there was an association between the Jo31GG and CT60GG genotypes and a reduced mean fluorescence intensity (MFI) of the total CTLA-4 (mCTLA-4 + cCTLA-4) molecules in CD4+ T cells from RRMS and SPMS patients in comparison with others, thus suggesting that the presence of the Jo31G allele and/or of the CT60G allele was associated with MS susceptibility [131]. This evidence concerns the gene CTLA4 and myeloid sarcoma.