CTLA4 and myeloid sarcoma: Although they found no differences in the allelic and genotypic frequencies between patients and controls with respect to single-loci variations, taking into account a putative interaction at the two loci, it was found that the T/G combination was more commonly recorded in MS patients compared to controls, thus highlighting that this allelic combination of the CTLA-4 polymorphisms could be implicated in MS susceptibility among Italians [125].