On the other hand, Čizmarević et al. have studied the possible role of CTLA-4 +49 A/G gene polymorphism in MS susceptibility and disease behavior in Croatian and Slovenian populations and found no significant differences in the CTLA-4 +49 A or G allele distribution between MS patients and the controls, thus suggesting that this polymorphism is not involved in MS susceptibility in the surveyed populations [132]. This evidence concerns the gene CTLA4 and myeloid sarcoma.