Furthermore, Karandikar et al. have demonstrated that the administration of anti-CTLA-4 mAb at different points during the relapsing experimental autoimmune encephalomyelitis (R-EAE) progression in female SJL mice aggravated the clinical disease and increased the T cell reactivity to inducing and relapse-associated epitopes [103]. Here, CTLA4 is linked to experimental autoimmune encephalomyelitis.