The same group of authors then analyzed the polymorphisms of exon 1 (+49A/G) and the promoter (-318C/T and -651C/T) regions of the CTLA-4 gene in Japanese MS patients and healthy controls and they found that there were no significant differences in the distribution of polymorphisms between the two groups and that there was no association between the clinical characteristics and the polymorphisms [137]. The gene discussed is CTLA4; the disease is myeloid sarcoma.