CTLA4 and myeloid sarcoma: Fukazawa and colleagues have studied Japanese patients with and without clinically or radiographically fulminant attacks, which are attack-related clinically or radiologically severe relapses but do not necessarily entail a severe disability, who satisfied the diagnostic criteria of MS and have found that the GG homozygous and G alleles of the CTLA-4 gene A/G coding SNP at position 49 in exon 1 were significantly more frequent in patients with fulminant attacks in comparison to those without [122].