SLC2A2 and type 2 diabetes mellitus: In this study, we aimed to analyze whether the genetic variants in the ATM, SLC22A1, SLC47A1, and SLC2A2 genes influenced the glycemic response to metformin in a cohort of patients with T2DM in Russia and, furthermore, to reveal the integrated contribution of the genetic factors and phenotypic features to therapeutic response, using the machine learning approach.