SLC22A1 and type 2 diabetes mellitus: To answer this question, we built several predictive models based on: (i) the patient’s genotype at the rs12208357 variant in SLC22A1 (the only variant that showed an association in the single variant tests); (ii) the genotypes at all of the tested variant sites; and (iii) the genotypes at all of the variant sites, as well as additional parameters, such as sex, age, BMI, WHR, plasma creatinine levels, and familial T2DM background.