The current systematic review, which investigated the genetic polymorphisms associated with BD comorbid to SUD, discovered nine polymorphisms related to seven genes with significant relationships.: rs11600996 (ARNTL), rs228642/rs228682/rs2640909 (PER3), PONQ192R (PON1), rs945032 (BDKRB2), rs1131339 (NR4A3), rs6971 (TSPO), and rs1106854 (TACR1). This evidence concerns the gene TACR1 and Behcet disease.