Published evidence implicated these 18 genes directly through population studies (GBP6, GSTO1, HHIPL1, INTS10, RGS16 and RNU6-679P), indirectly through association with other metabolic conditions (CCDC69, DNAH2, GALNT17, HERC5, KIF5C, MARCH2 and PRDM14) or through association with complications of T2D (CASC15, CCDC107, MIR147A, PFKFB3 and RNF166). This evidence concerns the gene RNF166 and type 2 diabetes mellitus.