These blocks represented genes associated with the neuronal system functioning (CACNA2D3, CHRNA7, NCALD, ADCY5, RYR2, SLC24A3, SLC 30A8 and MIP); genes associated with Notch signaling (MAML2 and HDAC9); one gene each representing the diabetes-breast cancer nexus (BRCA2); vitamin C metabolism (GSTO1); mTOR signaling (RPTOR); pyrimidine catabolism (DPYS) and endothelial function (NRP2). The gene discussed is RPTOR; the disease is diabetes mellitus.