Interestingly, among the high-risk variants listed, two frameshift variants were recurrent in unrelated patients, namely, c.1200delA; p.Lys400AsnfsTer15 in BHMT found in BC-F7P1 and BC-F10P6, and c.2626-2629delTTTG; p.Phe876LysfsTer16 in SH3PXD2B shared by BC-F2P10 and BC-F42P5 patients (Table 3). The gene discussed is SH3PXD2B; the disease is breast cancer.