The changes of expression levels of Fas receptor (FasR/CD95) and TRAIL receptors, including TRAIL-R1 (DR4) and TRAIL-R2 (DR5), were determined on the cell surface of CCA cell lines after treatment with genistein at concentrations of 25, 50, and 100 μM (Supplementary Figure S2 and Figure 6). The gene discussed is FAS; the disease is cholangiocarcinoma.