CASP3 and cancer: The effect of genistein to promote cancer cell death has been reported in several cancers but its lethal doses depended on types of cancer cells, i.e., 50-μM genistein could trigger apoptosis via increased expression of caspase-3 in HT29 cells [43] whereas 100-μM genistein promoted apoptosis in MCF-7 cells, reflecting the difference of drug sensitivity among cancer cell types [44].