NFKB1 and colon carcinoma: Compounds 4 and 5 were found to significantly downregulate Nuclear factor kappa B (NF-κB) in a human colon carcinoma cell line (SW480) induced by lipopolysaccharide (LPS) with the inhibitory rates of 75.9% and 73.1%, respectively, which were comparable with NF-κB inhibitor, MG132, (88.9% inhibition) [21].