The individual sensitivity to UVR-induced damage is highly variable and strongly influenced by a well-established skin cancer susceptibility gene: MC1R. The MC1R gene encodes a G protein-coupled receptor (GPCR) expressed in melanocytes that binds to several melanocortin peptides, including α-melanocyte-stimulating hormone (αMSH) [5]. The gene discussed is MC1R; the disease is skin neoplasm.