While BK124.1 is not a direct inhibitor of BCR-ABL1 kinase, it influences levels of BCR-ABL1 kinase and its key downstream kinases such as JAK/STAT and PI3K/Akt, known activators of survival and proliferation pathways in CML cells. Here, SOAT1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.