TNC and neoplasm: The method by which the extracellular matrix actively participates in edema formation in meningiomas, supporting the multifactorial hypothesis underlying PTBE, was interestingly reported by Kilic et al. [52]; they demonstrated that a correlation between tenascin (a matrix protein involved in several biological process such as embryogenesis, wound healing, reactive astrocytosis, and in some pathological processes, including tumor-associated angiogenesis) expression and peritumoral edema in meningiomas exists.