L1CAM and Lafora disease: An expression of L1CAM in ≥ 10% of the MELF component was found in 24 cases (41.4%) (Table 1) and was the only significant predictor of lymph node involvement on both univariate (p < 0.001) and multivariate analysis (p < 0.001) with a negative predictive value of 81.6% and a positive predictive value of 80%.