L1CAM and endometrioid adenocarcinoma: For instance, a L1CAM expression ≥10% in MELF glands might have a prognostic significance similar to LVSI; uterine-confined, low-grade endometrioid carcinoma with L1CAM positive glands might be included in the high-intermediate risk category according to the ESGO-ESTRO-ESP risk classifier [11].