L1CAM and neoplasm: These additional prognostic markers include histomorphological factors, such as tumor budding [17] and microcystic, elongated and fragmented (MELF) pattern of invasion [18]; immunohistochemical factors, such as transmembrane L1 cell adhesion molecule (L1CAM) expression [14] and SWI/SNF complex proteins expression [19]; and molecular factors, such CTNNB1 exon 3 mutations [14].