CD8A and melanoma: It has been shown that high lymphocytic infiltration such as CD3+ T cells, CD8+ cytotoxic T cells, and CD45RO+ memory T cells is associated with increased DFS and OS in patients with colorectal carcinoma, melanoma, ovarian cancer, head and neck cancer, bladder carcinoma, breast cancer, liver cancer, prostate cancer, and lung cancer [2,3,7,8,9,10,11,12,13].