A configured biomarker panel consisted of three mRNAs (SPINK7, PPL, and SEMA4B) and two miRNAs (miR-140-5p and miR-301a-3p) that were all significantly downregulated in the GC group, and yielded an area under the receiver operating characteristic (ROC) curve (AUC) of 0.81 (95% CI 0.72–0.89). Here, SEMA4B is linked to gastric cancer.