In parallel, TGF-β2 dictates disseminated tumor cell fate in target organs through TGF-β-RIII and p38α/β signaling, revealing a ‘seed and soil’ mechanism where TGF-β2/TGF-β-RIII signaling regulates DTC dormancy and defines restrictive (BM) and permissive (lung) microenvironments for HNSCC metastasis [46]. The gene discussed is TGFB2; the disease is neoplasm.