CYSLTR2 and neoplasm: Several other transcription factors and receptors are also involved in angiogenesis signaling, such as ELF5 and Cysteinyl leukotriene 2 receptor (CysLT2R), which trigger endothelial permeability, tumor angiogenesis, and lung metastasis by leukocyte infiltration and increased blood vessel permeability [60,61].