The most common RCC (ccRCC histotype) is linked to well-known altered-signaling pathways such as the von Hippel–Lindau (VHL), vascular endothelial growth factor receptor (VEGFR), and the phosphoinisitide-3 kinase/mammalian target of rapamycin (PI3K/mTOR) protein kinases. Here, VHL is linked to nonpapillary renal cell carcinoma.