Since macrophages in the BM can be phenotypically characterized as M1 or M2 macrophages, which are tumoricidal and pro-tumor, respectively [73], we carried out flow cytometric analysis of the BM of KC-HPC mice and found a significant decrease in M1 and increase in M2 macrophages compared with control mice (Figure 7C,D). Here, CALCA is linked to neoplasm.