TP53 and cancer: API inhibits tumor cell proliferation by inducing apoptosis leading to autophagy and cell cycle arrest at the G2/M phase and can also reduce cancer cell motility, thereby preventing cancer cell migration and invasion regulating PI3K/AKT, MAPK/ERK, JAK/STAT, NF-κB, p53 and Wnt/β-catenin signaling pathways [48,49].