In this present study, we are the first to show that apigenin treatment targets and suppresses miR-155 gene expression in the BM and pancreatic tumor, thereby elevating the SHIP-1 gene and protein expressions that corresponded with an increase in tumoricidal M1 TAM percentages and the infiltration of effector cytotoxic CD8+ T cells in tumors from mice (Figure 11). Here, INPP5D is linked to pancreatic neoplasm.