In this study, gene dependencies of each subtype-specific DLBCL entity were also described: the knockout of EBF1, IRF4, CARD11, MYD88, and IKBKB were selectively lethal in activated B-cell (ABC) DLBCL, whereas ZBTB7A, XPO1, TGFBR2, and PTPN6 were lethal in germinal-center B-cell-like (GCB) DLBCL. This evidence concerns the gene ZBTB7A and diffuse large B-cell lymphoma.