MYC and diffuse large B-cell lymphoma: Thereby, 1956 “DLBCL essential genes” whose inhibition resulted in significantly decreased cell fitness were described, including the oncogenes MYC, RHOA, SF3B1, MTOR, and BCL2. By contrast, TP53, MGA, PTEN, and NCOR1 were positively enriched in the screen, playing a role as tumor-suppressor genes.