GO analysis highlighted terms related to angiogenesis, cell migration, cell proliferation, and inflammation (Supplementary Figure S2b and Table S3), while transcription factor motif enrichment analysis additionally suggested an activation of interferon (IRF1) and TGF (SMAD2) signaling in tumor-draining LN fLECs (Supplementary Table S4). The gene discussed is IRF1; the disease is neoplasm.