In line with the immunofluorescence data, the absolute number and the relative frequency of medullary sinus macrophages (MSMs) tended to be reduced in tumor-draining LNs of Pdpnfl/fl × Prox1-CreERT2 mice (Figure 5h–j), whereas the expression of costimulatory molecules by these macrophages was not altered (Supplementary Figure S4g). The gene discussed is PROX1; the disease is neoplasm.