The German Testicular Cancer Study Group (GTCSG) proposed in 2006 the option of TSS in the case of the following parameters: a tumor in a solitary testis or bilateral tumors, diameter < 2 cm, no invasion of the rete testis, biopsies of the surgical bed, normal preoperative LH and testosterone levels and good patient compliance [30]. This evidence concerns the gene PLOD1 and male reproductive organ cancer.