The PI3K-Akt and MAPK signaling pathways both serve oncogenic roles in several malignancies, such as stimulating cellular proliferation, inhibiting apoptosis, promoting tumor invasion and metastasis, and stimulating angiogenesis, which in the case of the MAPK pathway is partially mediated by upregulation of VEGFA [34,35]. The gene discussed is VEGFA; the disease is neoplasm.