For example, activation of epidermal growth factor receptor (EGFR) signaling by prostate cancer cells in vitro has been associated with the formation of a specific subtype of larger EVs (up to 10 μM in diameter) [31], while in glioblastoma cells, overexpression of EGFR vIII promoted release of EVs enriched with focal adhesion and pro-invasive proteins [32]. This evidence concerns the gene COX8A and Familial prostate cancer.