NOTCH1 and cancer: Figure 1B shows the altered cancer-hallmark genes; alterations were seen in 22 (92%) of the 24 samples. The most frequently altered genes were KMT2C (6, 25%), HNRNPA2B1 (4, 17%), NOTCH1 (4, 17%), and TP53 (4, 17%). The oncogenic pathway analysis (Figure 1C) further showed that the most frequently altered pathways were the RTK-RAS pathway (16, 67%), Hippo pathway (13, 54%), WNT pathway (13, 54%), and NOTCH pathway (12, 24%).