It is interesting to note that among the cancer-hallmark genes (Supplementary Figure S2B), two genes, H3F3B (p < 0.0001, adj-p < 0.0001) and B2M (p = 0.0003, adj-p = 0.018), were enriched with alterations in EV-DNA, while 55 genes were enriched with alterations in tumor DNA. The gene discussed is B2M; the disease is cancer.