PIK3CA and ovarian cancer: As shown in Supplementary Figure S2A, 14 ovarian cancer genes were found to be enriched with alterations in tumor DNA, including TP53 (p < 0.0001, adj-p < 0.0001), PIK3CA (p < 0.0001, adj-p = 0.008), CSMD3 (p = 0.0002, adj-p = 0.01), CCND2 (p = 0.0007, adj-p = 0.03), ERBB2 (p = 0.003, adj-p = 0.06), and CCNE1 (p = 0.003, adj-p = 0.06), and no ovarian cancer genes were enriched with alterations in EV-DNA.