CD274 and neoplasm: The expression of PSMB8 (another top candidate gene for TT), known to be increased by IFN-γ and downstream of STAT1, has been shown to promote T cell infiltration in the tumor microenvironment by enhancing the repertoire of antigen presentation and to be an independent predictive biomarker for durable responses to ICI therapy (adjusted for tumor mutational load, IFN-γ signature, PDL-1 expression, and T-cell infiltration) [32].