So far, we have found that abnormal type 53BP1 expression is closely associated with carcinogenesis in several organs [12,13,14,15,16,17,18,19]; for instance, both large nuclear foci and diffuse patterns are significantly associated with high-grade urothelial carcinoma with chromosomal instability and poor prognosis in bladder cancers [15]. This evidence concerns the gene TP53BP1 and urothelial carcinoma.