Our previous experiments based on IF analysis of FFPE tissues showed that the presence of 53BP1 NF was increased in irradiated rat thyroid glands in a dose-dependent manner and that the presence of 53BP1 and γH2AX nuclear foci was frequently co-localized in human TFTs as well as irradiated rat thyroid glands, suggesting endogenous activation of the DDR pathways in tumor cells as a hallmark of genomic instability [12]. The gene discussed is TP53BP1; the disease is neoplasm.