CALR and neoplasm: Tumor cells that undergo ICD release not only TAAs but also DAMPs, such as high-mobility group box 1 (HMGB1), extracellular ATP, calreticulin (CALR), type I IFN, and heat shock protein (HSP), which are recognized by pattern recognition receptors (PRRs) expressed in myeloid and lymphoid cells, afterward inducing immune responses and establishing immune memory [102,103,146].