NUTM1 and osteosarcoma: Of these, there are three phase I trials in pediatric patients currently underway for the treatment of metastatic or unresectable nuclear protein of the testis (NUT) midline carcinoma, diffuse intrinsic pontine glioma, and several recurrent or refractory solid tumors, including brain, neuroblastoma, Ewing sarcoma, rhabdomyosarcoma, osteosarcoma, and rhabdoid tumors [125].