In fact, in pancreatic ductal adenocarcinoma [53], interleukin 1 beta (IL-1β) secretion from immune cells has emerged to be a potential initiator of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) signaling in fibroblasts, instructing them to produce a pro-tumorigenic secretome [31]. This evidence concerns the gene IL1B and pancreatic ductal adenocarcinoma.