The most common any-grade irAEs were rash (16.5%), hypothyroidism (15.6%), pruritus (13.8%), pneumonitis (12.8%), hyperthyroidism (11.9%), alanine transaminase increase (11.9%), gamma-glutamyltransferase increase (11.9%), aspartate aminotransferase increase (9.2%), and pyrexia (6.4%). The gene discussed is GPT; the disease is hypothyroidism.