An autoantibody panel including those seven markers (CD99L2, RPL22, HCFC1R1, ANXA4, FXYD7, HDAC3, TP53) could add valuable information about the IPMN grade for approximately one third of patients, whereas the multinomial lasso model could not find a biomarker panel of reasonable power to distinguish between IPMN-HR and IPMN-LR. Here, CD99L2 is linked to pancreatic intraductal papillary-mucinous neoplasm.