Immunohistochemical analysis of the tumor samples showed that the oncolytic adenovirus Ad5F11bSP-Rantes could replicate and express E1a in cancer cells, and E-cadherin expression was positive in cancer cells surrounding the necrotic area of tumor tissue, suggesting that Rantes up-regulated the expression of E-cadherin, and this may a molecular event of EMT reversal in cancer cells. The gene discussed is CDH1; the disease is cancer.