Cytological studies showed that oncolytic adenovirus Ad5F11bSP-Rantes can infect breast cancer cells with an enhanced infectivity, mediate the high expression of chemokine Rantes and play a role in inhibiting cancer cells, including TNBC and non-TNBC cell lines, and its killing effect on TNBC cancer cells is no less than that on non-TNBC cells. This evidence concerns the gene CCL5 and breast carcinoma.