We noted that only the Ad5F11bSP-Rantes group was positive for the expression of E-cadherin in cancer cells around the necrotic area of tumor tissue, but not in the other groups, suggesting that the expression of Rantes can up-regulate the expression of E-cadherin, which represents the molecular event of EMT reversal and the increase of homogenous adhesion in cancer cells. The gene discussed is CDH1; the disease is neoplasm.