It was found that both Ad5F11bSP-Rantes and Ad5F11bSP-DsRed could effectively inhibit the proliferation of breast cancer MDA-MB-231 and MCF-7 cells at low MOI values, but had no significant effect on MRC-5 cells (Figure 3B), suggesting that the oncolytic adenoviruses Ad5F11bSP-Rantes and Ad5F11bSP-DsRed could specifically replicate in breast cancer cells, selectively destroy cancer cells and produce an oncolytic effect. The gene discussed is CCL5; the disease is breast carcinoma.